The laboratory of Dr. Kotsopoulos is testing if increasing the amount of normal BRCA1 in patients with BRCA1 mutations can prevent cancer. To do this they are developing a cell-based test to screen for drugs, small molecules or natural compounds that can increase BRCA1 protein levels. They will then validate what they find in the screen on a variety of pre-clinical models that have only one normal copy of BRCA1.
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2017