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Identification of natural compounds that are toxic to BRCA2 mutant stem cells but not normal stem cells

Debananda Pati, Ph.D.
Professor, Baylor College of Medicine
Baylor College of Medicine

Dr. Pati was awarded funds to find natural compounds that kill cells that are deficient for BRCA2 as well as validate already identified hits from a pilot screening program. The idea is that one of these compounds could be tested further as a drug that could eliminate BRCA2 deficient cells (those that have lost the normal copy of BRCA2) in humans who carry a BRCA2 mutation before the cells develop into a cancer.

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