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Immunoprevention of BRCA1-associated breast cancer

Judy Garber, M.D., M.P.H.
Professor and Director, Center for Cancer Genetics and Prevention
Dana-Farber Cancer Institute, Harvard Medical School

Dr. Garber’s group is part of a multi-institutional team investigating TP53 as a preventative vaccine target in BRCA1-associated breast cancers. The overarching hypothesis of the project is that progression of BRCA1-associated pre-invasive to invasive cancer is driven by the immune environment and that p53 is a reasonable target for immunization in BRCA1 mutant tumors. They hypothesize that initially there is a protective immune response that eradicates early tumors. With time there is a shift to a more immunosuppressive state which allows immune escape and invasive tumor development. Dr. Garber’s group is identifying recurrent tumor antigens other than mutant p53 in BRCA1-mutant neoplasia. To achieve this, they are working with the Broad Institute to sequence tumors and normal surrounding tissue. The entire team is part of the effort to assemble a collection of archived breast tissues from BRCA1 mutation carriers and working to characterize the immune microenvironment of invasive and in situ breast tumors in cancer gene mutation carriers.

One Arts Plaza
1722 Routh Street | Suite 770
Dallas, Texas 75201
Phone: 1-844-437-4891
Donate at Southwestern Medical Foundation/CPI
CPI is a 501(c)(3) organization 47-3425850 



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